Liver stiffness changes during meal times

Meal ingestion markedly increases liver stiffness suggesting the need for liver stiffness determination in fasting conditions.

INTRODUCTION The introduction of noninvasive liver stiffness (LS) determination has heralded a new stage in the diagnosis and treatment of liver fibrosis. AIM We evaluated the effect of food intake on LS in patients with different degrees of liver disease. PATIENTS AND METHODS We evaluated 24 patients (F≤1, n=11 and F> 1, n=13). LS (Fibroscan®) and portal blood flow (PBF) (Doppler ultrasoun...

Liver stiffness measurements increase after meal ingestion--an important step towards standardization.

Effect of Meal Ingestion on Liver Stiffness in Patients with Cirrhosis and Portal Hypertension

BACKGROUND AND AIMS Liver stiffness is increasingly used in the non-invasive evaluation of chronic liver diseases. Liver stiffness correlates with hepatic venous pressure gradient (HVPG) in patients with cirrhosis and holds prognostic value in this population. Hence, accuracy in its measurement is needed. Several factors independent of fibrosis influence liver stiffness, but there is insufficie...

Nucleic acid changes during liver regeneration.

Nucleic acid studies on growing normal and pathological tissues have gained ever increasing momentum in recent years. Several investigators (l-7) have presented evidence indicating a high nucleic acid content for neoplastic tissues. It has recently been shown in this laboratory (8-13) that there is an increase in the nucleic acid content of the liver, kidney, and lung of mice bearing a transpla...

Changes in chromatin proteins during liver regeneration.

The metabolism of chromatin proteins of rat liver has been examined during the prereplicative period following partial hepatectomy. Within 8 hours after partial hepatectomy, isolated chromatin exhibits a 7% decrease in its histone to DNA mass ratio compared to sham-operated and zero time controls. The time course and amount of this decline correlate well with the previously published pattern of...